connection refused / HTTP 522

Nothing is listening — this is a server or startup problem, not your install

why

Connection refused means nothing is bound to that port; HTTP 522 is Cloudflare reporting that the origin server did not answer. Either way the failure is on the far side. Reinstalling the client, switching networks or disabling your firewall cannot fix a service that is down or never finished starting.

what to do

For a public service, check its status page before touching anything locally. For your own process, it started but its service layer never came up — read the startup log from the beginning and find the first failure, not the last line.

traced · STRING-DB outage + CyREST startup, 2026
This is one entry from BioErrors, a catalogue of bioinformatics error messages that point at the wrong thing. Every entry was traced to its real cause before it was written down.
If your error is not in it, paste it there and it gets traced and added.